We use animals in research because they’re so similar to humans. So what can be gained from using marsupials, such as opossums and wallabies, that are so far from humans on the evolutionary family tree? James Turner, a researcher at the MRC National Institute for Medical Research (MRC NIMR), tells us why finding similarities in these more distant relatives can lead to important and surprising results.
For many years, scientists have used laboratory mammals such as monkeys, mice and rabbits to understand how human diseases develop and how they can be treated. The DNA make-up, or genome sequence, of these animals is very similar to that of humans, and we’re all members of the largest class of mammals (the ‘eutherians’), so they make good experimental models.
But during the past few years, my group at the MRC NIMR, along with other researchers, have started using a more unusual type of mammal, the ‘metatherian’, or marsupial, to understand human biology. Marsupials, such as opossums and wallabies, can provide us with a level of insight that other mammals cannot. Read more