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Posts tagged ‘tissue samples’

Capital for tissue banks – what we want from charities

Last month we invited applications for a £5-million pot of capital investment to partner with charities to establish or enhance human tissue banks and linked data. Katherine Nightingale spoke to MRC Programme Manager Dr David Crosby about the role of charities in tissue banking and what we’re looking for from charity partners.

Why do we need tissue banks?

Tissue banking is a really important area for research. If you want to understand the mechanisms of human disease and identify appropriate targets for new treatments, then tissue from patients with a particular disease is a fantastic resource. You can study the disease processes in cellular form, screen therapies, develop diagnostics and validate what you’ve learned from other research such as animal studies.

A rack of tissue samples

A rack of tissue samples (Image: UCL)

What’s the purpose of this investment?

Tissue banking isn’t cheap and it’s logistically complex. We’re making a one-off investment to fund tissue bank infrastructure. This includes the people, equipment and facilities required to collect, characterise, curate and store the tissue and its associated data, and make it accessible to the research community.

The awards will concentrate on areas of existing strength either in tissue banking or in important lines of research that can benefit from tissue banking.

Applicants will need to describe how a proposed tissue bank will catalyse new science through new tissue banking and data linkage approaches. Read more

Getting the best out of biological samples

Tissue samples stored in microscope slides

Tissue samples (Image: euthman on Flickr under CC BY-SA 2.0)

Hundreds of thousands of biological samples such as blood, urine and tissue blocks are kept in research institutions and hospitals across the UK. Within them may lie the answers to some of the biggest questions in medical research. Getting the best out of samples relies on donors understanding what they may be used for and researchers feeling confident about when they can use and share them. Here Professor James Ironside, Professor of Clinical Neuropathology at the University of Edinburgh, tells us about new MRC guidance on the practicalities and ethics of using biological samples.

“It’s better not to restrict the possible use of the sample because by restricting it you’re increasing the chance that it’ll go to waste. You want the highest probability that something good will come from it.”

Those are the words of a patient surveyed about the public’s views on the use of biological samples in medical research [1]. So how do we go about increasing the chances that samples will be useful?

Samples of human biological material have always been crucial to medical research, but as we move into an era in which huge amounts of data can be analysed easily, getting the best out of each and every sample is becoming more important than ever. Read more