Regenerative medicine is a fast-moving, interdisciplinary field, looking for ways to repair or replace parts of the body that are diseased or damaged. Now there’s an established and growing UK research community, we’re changing the way we fund this type of research. Two researchers explain why our continued support for this field – from the early discovery stage to translation into the clinic – will help deliver life-changing treatments for currently incurable conditions.
Adult stem cells from the tissue lining the human knee joint, grown in a dish. These cells can repair
damaged cartilage and are being trialled in the clinic. Individual stem cells are labelled with different fluorescent colours. Image credit: Nathan White, University of Aberdeen.
Professors Irv Weissman and Ravi Majeti at Stanford University and Professor Paresh Vyas at the MRC Molecular Haematology Unit in Oxford, are working on an antibody from the Stanford investigators that enables the immune system to detect and kill cancer cells. They are now testing whether it’s safe and effective for use in people with blood cancer. In this week’s blog they tell us how they collaborated across the Atlantic to get public funding for a project that has led to a spin out with multiple backers and a promising clinical trial.
What if we could make our immune system fight cancer like it fights infection?
These aren’t the only teams in the world grappling with that question but for Professor Irv Weissman and Professor Paresh Vyas, the solution feels tantalisingly close for patients with blood cancer. Read more
New technology is helping scientists study the secrets of single cells in more detail than ever before. Dr Roy Drissen at the MRC Weatherall Institute for Molecular Medicine tells Sylvie Kruiniger how single cell technology has helped them discover a previously unknown stage in blood cell development which may have implications for the future of leukaemia treatment.
“Before Galileo invented the telescope, we could just see Jupiter. With the telescope, we saw that Jupiter had moons. That’s what single cell technology is doing for biology: where we used to think there was only one type of cell, we can now see several.” Read more