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Posts tagged ‘NIHR’

Blood donation: the lifeblood of the NHS

As the NHS turns 70, Petra Kiviniemi delves into the MRC archive to reveal a history of blood donation closely intertwined with the birth of the NHS.

Still from the wartime public information film Blood Transfusion Service*

Still from the wartime public information film Blood Transfusion Service*

Every two seconds, someone needs blood. Blood donations help millions of people, and many would not be alive today if it wasn’t for the generosity of donors and care by our NHS.

The experience of being a volunteer blood donor was a very different picture back in the 1920s. Back then, nearly a century ago, and more than 20 years before the birth of the NHS, donations needed to be directly transferred from one person to another.

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The power of the phenome

London 2012 Anti-Doping Science Centre

London 2012 Anti-Doping Science Centre (Image copyright: GlaxoSmithKline)

Today Prime Minister David Cameron announces that the London 2012 Anti-Doping Science Centre in Harlow will live on after the Olympic Games as the MRC-NIHR Phenome Centre. Katherine Nightingale spoke to Frank Kelly, one of the principal investigators at the new centre and Director of the Analytical & Environmental Sciences Division at King’s College London, to find out what phenomes can teach us about disease.

Let’s start with the basics, what exactly is a phenome?

Well, lots of people have heard of the genome — it collectively describes an individual’s genetic material. The phenome describes all the other chemistry of our body; all the molecules in our body. This mixture of molecules changes every minute of every day and depends on the way we lead our lives, the environment in which we live and how our bodies respond.

How does studying phenomes help researchers understand disease?

When genomic science began we all thought that once we’d figured out human genomes we’d understand why some people get disease and some people don’t. But it turns out that our genomes only explain the causes of a fifth of chronic diseases like heart disease — in fact, environmental factors are behind the vast majority of chronic diseases.

By environment I mean the totality of environmental exposure, from the type of food we eat to where we live, the type of job we have, the level of stress we experience, the air we breathe, the water we drink, the chemicals we use to clean our homes. All of these in combination will lead to some people developing chronic disease at some point in their lives. Read more