Jane Patrick, a PhD student at the Wellcome Trust Sanger Institute, studies zebrafish to learn more about muscle diseases such as muscular dystrophy. She explains her work in her commended entry for the 2014 Max Perutz Science Writing Award.
Which muscles are you using right now? Perhaps you’re absent-mindedly shaking a leg or munching on food? At the very least, I expect you’re breathing. The chances are you haven’t even noticed your muscles working. Most of us take our muscles for granted, but for a child born with an inherited muscle disease, such as myopathy or muscular dystrophy, it isn’t that simple.
These children have a faulty copy of a gene meaning their muscle doesn’t develop or work properly, so they have weak or degenerating muscles from birth or a very young age, and often developmental problems too. The problem is there are a vast number of different genes that can be affected, some unique to one patient, which gives a huge range of symptoms and makes it difficult to find an effective treatment. Read more