Reproducibility isn’t something that can be solved without considering the bigger research picture. So as part of efforts to improve the quality of research, we’ve collected tips and resources – relevant to each stage of the research process – from across the MRC community to help. Isabel Baker reports.
Methods are us
Good science needs good methods. Good methods ensure that health research and policy are built on the best possible evidence. Using robust, bullet-proof methods that are reliable and repeatable can also improve efficiency. Efficiency is important, as it’s not just taxpayers’ money at stake; valuable samples from humans and animals can often be used only once, and time donated by volunteers is precious.
To understand the roles of different genes, Dr James Brown and colleagues at the MRC Harwell Institute are part of a project trying to find out what every single mouse gene does. To help speed things along, they have developed new software to analyse images of mouse embryos.
Our 20,000 genes provide the instructions for everything our body does. But we don’t yet know what each one is responsible for. We share 90 percent of our genes with mice so finding out their ‘function’ could help us understand more about human disease. Read more
Dr Mary Lyon, an important figure in the field of mouse genetics, died in December. Here Katherine Nightingale looks back on her career, from a ‘titular’ degree to her impact on generations of scientists, via a discovery in the early 1960s which explained a fundamental difference between men and women in the inheritance of disease.
A portrait of Mary Lyon by artist Dr Lizzie Burns (Image copyright: Dr Lizzie Burns)
It’s not often that the MRC names a building after a scientist, even with our roll-call of scientific greats. But at MRC Harwell in Oxfordshire, the MRC Mary Lyon Centre teems with life — murine life that is. Opened in 2004, the centre is a national facility for mouse genetics where genetically modified mice are produced, cared for and studied.
Mary Lyon, who died on Christmas day 2014 aged 89, worked with mice throughout her scientific career, becoming one of the foremost geneticists of the 20th century through her research on mice with mutated genes. She made her most famous discovery, named ‘lyonisation’ in her honour, during her time at MRC Harwell. Read more