Nicola Hodson takes apart the transport systems in cells to see how they work and how their disruption might cause disease. Here, in her shortlisted article for the Max Perutz Science Writing Award 2012, she invites us into the microscopic city of the cell.
I’m sitting in Cambridge on a Monday morning observing the relentless chaos of commuter traffic. Cargo-bearing vehicles zip in, out and around the city, efficiently delivering goods to their required locations. All this hustle and bustle is essential to the integrity of such a busy city, without it everything would grind to a halt. I pull my chair back from the microscope in wonder, for what lies before me is not actually a city, but a single human cell.
My research focuses on how vehicles transport cargo into, out of and around a cell. A cell, just like a city, needs particular things to keep going. In a city, food needs to be delivered to supermarkets or to families who have ordered their groceries online. Likewise, a cell needs to bring nutrients inside and just like the supermarkets and the online shoppers, it can select exactly what it wants delivering and when. Read more