As a runner-up in our 2017 Max Perutz Science Writing Award, PhD student Sophie Quick, of the MRC Centre for Regenerative Medicine at the University of Edinburgh, explains why her research – focused on a condition called small vessel disease which can cause dementia – matters.
Strawberry picking might not seem like the place for scientific inspiration, but on a warm summers day just weeks into my PhD, I returned not just with a punnet of Scotland’s finest fruits but a new take on my research. Sheltered by a gently flapping plastic roof I bent to pluck a handful of ripe berries, spotted fine tubes running along the soil and was struck by an idea.
In her runner-up article for our 2017 Max Perutz Science Writing Award Nadine Mirza, a PhD student at the University of Manchester, explains why changes are needed to a routine test for diagnosing dementia, unbiased by language or culture, to prevent incorrect diagnoses.
Have you heard the saying “No ifs ands or buts”? Associated with grannies and teachers, you’d be hard pressed to find someone who hasn’t. It’s also a saying used in the ACE, a test implemented across the UK to detect dementia. An individual has to read the saying out loud with correct pronunciation. When directly translated into Urdu it loses meaning and becomes gibberish and reading out gibberish isn’t a smooth task. Even a fluent Urdu speaker might fail. But would we attribute that to dementia? Apparently, yes.
Alois Alzheimer first described his eponymous disease a century ago, but there are still no effective treatments. For World Alzheimer’s Day, Professor Bart de Strooper, Director of the UK Dementia Research Institute, asks why that is, and tells us how that might all be about to change.
Professor Bart de Strooper
In the early 1900s, a German neurologist called Alois Alzheimer became obsessed with studying an Asylum patient in her 50s, who had started to show unusual behavioural changes, including short-term memory loss. After her death he examined her brain and discovered structures known as amyloid plaques and neurofibrillary tangles – the hallmarks of what became known as Alzheimer’s disease. So why, when we’ve known about the disease for so long, are there still no treatments? Read more