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Posts from the ‘From the community’ Category

Cryo-electron microscopy: big kit solving life’s smallest puzzles

Since its invention in the 1980s, the UK has led developments in cryo-electron microscopy – a technique allowing scientists to zoom in on the inner-workings of tiny molecules. A new imaging centre at the MRC-University of Glasgow Centre for Virus Research is now expanding the UK’s powerful microscope offering. Director Professor David Bhella shares his grand plans.

So what exactly is cryo-electron microscopy?

David Bhella with imaging computer

Cryo-electron microscopy, or cryo-EM for short, is a powerful microscope technique. It’s different from imaging with normal microscopes as it uses beams of electrons, instead of light. Structural biologists use this technique to take pictures of biological samples at near-atomic scale, frozen in their natural state. It’s a faster and more effective way of looking deep inside molecules compared to other structural biology tools. Read more

How do we help people living with mental health conditions live longer, healthier lives?

Psychiatrist and Population Scientist Professor Simon Gilbody of the University of York, has just been awarded £1 million to build his new “Closing the gap network”. With 20 years’ experience in healthcare, Simon has seen how lives can be transformed if the same emphasis is placed on both physical and mental health. Starting this year, the special network of experts from the sciences to the arts will try to understand and tackle the root causes of why the health and life expectancy of people with severe mental ill health is so poor.

Simon Gilbody

Image credit: University of York

What is the ‘mortality gap’ and what are we doing to tackle it?

People who use mental health services experience the poorest physical health and most profound health inequalities of any section of the UK population.

Diabetes, heart disease and chronic respiratory illness, are two to three times more common in this group of people than for people with good mental health. Life expectancy is reduced by 20 to 25 years, and a person developing schizophrenia in their 20s can only expect, on average, to live into their 50s.

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How secure data sharing can help us treat dementia

Dementias Platform UK is a world-leading digital treasure trove, holding health data from millions of people, to help understand and treat dementia. Their one-stop shop gives researchers access to health data for dementia research and recognises contributions from researchers across the pay grade. Director Professor John Gallacher explains why it’s good for science and scientists.

Professor John Gallacher, Director of the Dementias Platform UK

Professor John Gallacher, Director of the Dementias Platform UK

In the UK, we’re fortunate to have a growing, rich resource of data from people that take part in studies which follow their health and lifestyle choices over time, known as cohort studies.

But there isn’t a single standardised way of storing and analysing this information. Without the right tools to search, interrogate and analyse this information, the data can seem impenetrable.

At Dementias Platform UK (DPUK) we have a solution – a place for researchers to access all the data they need to answer some of the toughest questions about dementia. We want the best minds to access the best data, regardless of their location.  Read more