Jane Dunnage was forced to give up work due to the rare autoimmune condition systemic lupus erythematosus, also known as SLE or lupus. After 10 years of being a Trustee for the charity LUPUS UK she now leads patient involvement for the MRC-funded MASTERPLANS* study. She explains why research needs the patient voice.
Jane Dunnage (Image copyright: D Boyraz)
I had to give up my job in communications about 20 years ago because of the symptoms of lupus. It was affecting my eyes and my joints, and the fatigue was extremely disabling. I found it impossible to carry on working.
But it was another four or five years before I was actually diagnosed. I became a ‘pass the parcel’ around different consultants and departments for a year. Then somebody at long last recognised the link between the wide-ranging symptoms and said, “I think you have lupus”.
Research published today, funded by the MRC* and the Alzheimer’s Society’s Drug Discovery programme, has made important progress in the search for new treatments for dementia by re-purposing old drugs. Dr Louise Walker, Research Communications Officer at the Alzheimer’s Society, spoke to the scientist who led the research, Professor Giovanna Mallucci at the MRC Toxicology Unit, to find out more.
Alzheimer’s disease and other degenerative brain diseases are characterised by the presence of misfolded proteins in the brain. These proteins are thought to have toxic effects on brain cells, but exactly how they contribute to dementia still remains a mystery.
In 2016, the results of a trial led by Professor Jonathan Green from the University of Manchester showed long-term improvement of autism symptoms in children for the first time. But what if we could reduce the severity of these symptoms by acting even earlier? In National Autism Awareness Month, Jonathan describes why the results of his new collaborative study give cause for optimism.
Jonathan with one of his study participants. Image credit: Jonathan Green
Intense scientific work to understand autism and its causes has continued ever since it was first identified over 70 years ago. But good quality research to develop effective interventions has only really accelerated since the turn of the century.
My research focuses on helping parents of children with autism communicate with their child. We work with parents, using video feedback techniques, to help them understand and respond to their child’s communication style.